The Scientific Evidence

Discovery

Mitchell SM, et al. Evaluation of methylation biomarkers for detection of circulating tumor DNA and application to colorectal cancer Genes 2016

Mitchell, S.M., et al. A panel of genes methylated with high frequency in colorectal cancer. BMC Cancer 2014

LaPointe, L.C., et al. Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing. PLOS One. 2012

LaPointe, L.C., et al. Map of differential transcript expression in the normal human large intestine. Physiol Genomics 2008

Clinical Validation

Murray, et al. Validation of a Circulating Tumor-Derived DNA Blood Test for Detection of Methylated BCAT1 and IKZF1 DNA.  JALM 2017

Symonds, E.L., et al. Circulating tumor DNA before and after resection for colorectal cancer. Presented at ASCO Annual, 2017

Symonds, E.L., et al. The relationship between the degree of aberrant methylation in colorectal cancer tissue and appearance of tumor-derived DNA in blood. Presented at ASCO GI Symposium, 2017

Symonds, E.L., et al. Predictors of circulating tumor-derived methylated BCAT1 and IKZF1 DNA in colorectal cancer patients.Presented at ASCO GI Symposium, 2017

Minhhuyen, N. T., et al. Biomarkers in colorectal cancer screening. JNCCN 2016

Pedersen, et al. A two-gene blood test for methylated DNA sensitive for colorectal cancer. PLOS One 2015

Pedersen, et al. Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia. BMC CANCER 2015

Symonds, E.L., et al. A blood test for methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for detection of colorectal neoplasia. Clinical and Translational Gastroenterology 2015

Clinical Utility

Young, G. P., et al. A cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumor-derived DNA with CEA for detection of recurrent colorectal cancer. Cancer Medicine 2016